Mass Appeal: Disrupting Drug Discovery Research from Assay Development to Lead Compound using Mass Spectrometry

In this white paper, we explore important aspects to consider when choosing a mass spectrometry (MS) approach for small molecule high-throughput screening applications, with a focus on different strategies for sample preparation to maximize the benefits of MS analysis. We highlight the value of combining polymeric enrichment arrays with matrix assisted laser desorption ionization (MALDI) MS, which offers unique solutions for measuring biochemical activities and binding interactions to accelerate and advance small molecule drug discovery research from assay development to lead compound.