Scientific Resources
Search our resources — articles, case studies, presentations, and more — for answers to your biggest assay inquiries and drug discovery questions.
Tech Note
Measuring kinases and phosphatases using high-throughput MALDI and PEAs
Download our tech note to learn how surface chemistry and MALDI MS is driving the discovery and characterization of kinase and phosphatase inhibitors.
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Assay development and HTS of PAPD5 inhibitors using an innovative mass spectrometry platform
The Poly Adenosine Polymerase Associated domain 5 and 7 proteins regulate RNA stability by adding adenosine nucleotides to the 3’ end of various RNAs, including telomeric RNA, oncogenic microRNAs (miRNA) and viral RNA such as Hepatitis B Virus (HBV). Inhibitors of PAPD5 and PAPD7 offer promising therapeutic avenues to combat certain cancers, telomere-biology disorders, and…
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Why combining MALDI-MS and PEAs became the perfect assay for “me”
Download this tech note to see how combining MALDI MS and PEAs is ideally suited for measuring methyltransferase activities and characterizing MTase inhibitors.
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Measuring kinases and phosphatases using high-throughput MALDI and PEAs
Download our tech note to learn how surface chemistry and MALDI MS is driving the discovery and characterization of kinase and phosphatase inhibitors.
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High-throughput assays for RNA polymerases using MALDI MS and PEAs
Download our tech note to learn how the combination of surface chemistry and MALDI MS offers a direct measurement of polymerase activities and characterization of inhibitors.
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From Prediction to Proof: Why AI/ML Drug Discovery Still Needs Experimental Data
Artificial intelligence, machine learning, and large language models (collectively referred to here as “AI/ML”) are genuinely reshaping how scientists imagine, prioritize, and advance new therapies. The promise of AI/ML is ubiquitous. We constantly see headlines touting how AI/ML will compress years of drug discovery into months and reduce the costs of identifying new therapies. However,…
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Assay development and high-throughput screen for Sortase A inhibitors using an innovative mass spectrometry platform to combat antibiotic resistant bacteria.
Abstract: Bacterial virulence is a driving mechanism of infection and disease. In Methicillin-sensitive and -resistant Staphylococcus aureus (MRSSA/MRSA), Sortase A plays a crucial role in bacterial virulence, where its transpeptidase activity anchors specific proteins like Staphylococcal protein A (SpA) to the cell wall enabling colonization and infection as well as facilitating resistance to antibiotics. Sortase…
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