ASMS using MALDI MS and polymeric enrichment arrays (PEAs) for molecular glue discovery

The identification of small molecule binders to a distinct target is a common strategy to initiate drug discovery efforts, including for modalities that induce proximity, such as molecular glues. Affinity selection mass spectrometry, also known as ASMS, combined with polymeric enrichment arrays, offers unique benefits for identifying not only binders to virtually any target, including proteins and oligonucleotides such as RNA, but it also offers opportunities to detect proximity. Download this tech note to discovery how Peapod Bio’s innovative ASMS approach identified a small molecule binder and could also detect ternary complex formation.